Aldose Reductase

Related Products

Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney.

Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it.

Aldose Reductase Related Products (133)
Antibodies (2)

By Effects:	Inhibitors (124) Substrate (1) Degrader (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N1517

Ganoderic acid C2		99.72%
Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC₅₀ of 43.8 µM.

HY-15314

Ranirestat	Inhibitor
Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC₅₀s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a K_i of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas.

HY-19687

Zopolrestat	Inhibitor	99.92%
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC₅₀ of 3.1 nM. Zopolrestat is used for the research of diabetic complications.

HY-129586

Govorestat	Inhibitor	99.93%
Govorestat (AT-007) is an orally active brain-penetrant aldose reductase inhibitor with an IC₅₀ value of 100 pM. Govorestat has the potential for galactose-1-phosphate uridyl transferase deficiency research.

HY-N10361

Drupanin	Inhibitor	99.35%
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers.

HY-109154

Obafistat	Inhibitor	99.92%
Obafistat is a potent aldo-keto reductase AKR1C3 inhibitor with an IC₅₀ of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4).

HY-16255

Imirestat	Inhibitor	99.59%
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.

HY-13633

Exisulind	Inhibitor	98.04%
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac. Exisulind inhibits aldose reductase with an IC₅₀ of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications.

HY-106198

Lidorestat	Inhibitor	99.50%
Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC₅₀ of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation.

HY-N0309

Soyasaponin Ba	Inhibitor	99.47%
Soyasaponin Ba is a soyasaponin isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitors (ARI).

HY-B1202

Alrestatin	Inhibitor	99.67%
Alrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.

HY-152188

AKR1C3-IN-9	Inhibitor	99.77%
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC₅₀ value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line.

HY-18967

Caficrestat	Inhibitor	99.74%
Caficrestat (AT-001) is an orally active aldose reductase inhibitor. Caficrestat can be used in the study of diabetic cardiomyopathy.

HY-116239

Zenarestat	Inhibitor	99.35%
Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats.

HY-N2461

Ganoderic acid C6		99.40%
Ganoderic acid C6 has aldose reductase inhibitory activity.

HY-162325

WJ-39	Inhibitor	99.60%
WJ-39 is an orally active aldose reductase (AR) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis.

HY-151231

6-Hydroxyluteolin	Inhibitor	98.15%
6-Hydroxyluteolin (Compound 17) is a flavonoid compound. 6-Hydroxyluteolin has an inhibitory effect on aldose reductase (AR) .

HY-122917

Danshenol A	Inhibitor	99.67%
Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC₅₀ of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research.

HY-171115

Pyrone-211	Inhibitor	99.32%
Pyrone-211 is a potent GPR84 agonist and AKR1C3 inhibitor. Pyrone-211 participates in an expanded polyamine pathway.

HY-118819

5-Bromo-3-phenyl salicylic acid	Inhibitor	98.00%
5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with K_i of 140 nM.

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Aldose Reductase

Aldose Reductase

Aldose Reductase Related Products (133)

Antibodies (2)

Aldose Reductase Related Products (133):